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Best Antibiotic Cream for Skin Infection: 7 Effective Topical Options

Best Antibiotic Cream for Skin Infection: 7 Effective Topical Options
Shweta Chaubey

Bacterial and fungal skin infections can be tricky to deal with. Most commonly, dermatologists prescribe using antibiotics to treat bacterial infections. According to an article by Medical News Today, “they work by killing bacteria and preventing them from multiplying.” Some of the most popular and effective antibiotic ointments are Bacitracin and Neosporin.  

Neosporin vs Bacitracin 

Bacitracin and Neosporin are brand-name drugs for bacterial growth. These are both considered the best antibiotic creams for skin infections. While Bacitracin contains only one active ingredient – Bacitracin, Neosporin, is a combination drug with many active ingredients. Active ingredients in Neosporin include Bacitracin, polymyxin b, and neomycin. The difference between the two antibiotic creams for infections is that some people are Neosporin but not Bacitracin due to the many active ingredients present in the former.  

When choosing an over-the-counter antibiotic ointment, make sure to go through the ingredients. If you have questions, it’s better to ask your doctor beforehand. To find the right antibiotic ointment, HPFY is here with a list of its best antibiotic creams for skin infection, for you to choose from.  

7 Best Antibiotic Cream for Skin Infection 

1. Dynarex Triple Antibiotic Ointment 

FSA Eligible Items FSA Approved

It is a topical, first-aid antibiotic ointment specifically used to prevent infections in minor cuts, scrapes, and burns. It inhibits bacterial growth and is ideal for clinics, schools, first aid kits, and home use. 

Active ingredients 

  • Bacitracin 
  • Neomycin 
  • Polymyxin B 

Dynarex Antibiotic Ointment Features 

  • Reduces infections 
  • Individually packaged 
  • Ideal to take on travels  
  • Triple ointment formula 
  • Quickly heals abrasions, burns, and cuts 

Dynarex Triple Antibiotic Ointment


2. Bacitracin Antibiotic Ointment 

FSA Eligible Items FSA Approved

Bacitracin is an excellent first-aid or emergency supply item. It is a polypeptide antibiotic to treat bacterial skin infections and prevent minor cuts and scrapes from getting infected. This is one of best antibiotic creams for skin infections and kills many harmful bacteria before they start growing.   

Active Ingredients 

  • Bacitracin Zinc (Equal to 500 Bacitracin Units) 

Bacitracin Ointment Features 

  • Inhibits bacterial cell wall synthesis 
  • It is readily absorbed through macerated skin 
  • Works well as a single-agent ointment 
  • It can also be used in combination as a triple therapy ointment 

Bacitracin Antibiotic Ointment


3. Water Jel Triple Antibiotic First Aid Ointment 

FSA Eligible Items FSA Approved

It is a soothing, lubricating, non-stinging topical ointment for skin infection and comes in single-dose packaging to eliminate the chances of cross-contamination and protect the caregiver. It soothes and relieves burning, itching, cracking, chafing, and redness caused due to fungal conditions. The gel is enriched with Vitamin E and skin conditioners

Active Ingredients 

  • Zinc Oxide 
  • Petroleum 
  • Bacitracin Zinc 
  • Neomycin Sulfate 
  • Polymyxin B Sulfate 

Features of Water Jel Antibiotic Ointment  

  • Fragrance-free 
  • Non-sensitizing 
  • CHG compatible   
  • Works as a barrier 
  • Pediatric safety tested 
  • Contains emollients to moisturize 

Water Jel Triple Antibiotic First Aid Ointment


4. Perrigo First Aid Antibiotic Ointment  

FSA Eligible Items FSA Approved

It is a fast-acting antibacterial cream that works well for the treatment of minor wounds and burns. This affordable cream for skin infections is a must in your first aid kit. 

Active Ingredients 

  • Bacitracin 
  • Neomycin 
  • Polymyxin B 

Features of Triple Antibiotic Ointment 

  • First aid antibiotic 
  • Container type - tube 
  • Long-lasting protection against infection 
  • Treats all kinds of minor cuts, burns, and abrasions 

Perrigo First Aid Antibiotic Ointment


5. Sunmark Triple Antibiotic Ointment  

FSA Eligible Items FSA Approved LatexFree Latex Free

This first-aid topical antibiotic ointment is used to treat and prevent infection and comes in a convenient tube for easy application. It temporarily relieves pain or discomfort and reduces the chances of developing moisture wounds.  

Active Ingredients 

  • Bacitracin 
  • Neomycin 
  • Polymyxin B 
  • Pramoxine HCl 

Sunmark Antibiotic Ointment Features 

  • Latex-free 
  • Comes in 1 oz. Tube 
  • Fast-acting ointment 
  • Topical first aid ointment 
  • Maximum strength pain relief 
  • Prevents bacterial build-up on the wound site 

Sunmark Triple Antibiotic Ointment


6. Polysporin Bacitracin / Polymyxin B First Aid Antibiotic Ointment 

Polysporin combines the power of bacitracin zinc with polymyxin B sulfate to form a strong antibiotic without Neosporin. This double-strength antibacterial cream soothes the wound site, forms a protective coating, and minimizes the appearance of scars.  

Active Ingredients 

  • Bacitracin Zinc 
  • Polymyxin B Sulfate 

Features of Polysporin 

  • Odorless 
  • Non-stinging 
  • Helps prevent infection 
  • #1 dermatologist-recommended 

Polysporin Bacitracin / Polymyxin B First Aid Antibiotic Ointment


7. Dynarex Bacitracin Ointment  

FSA Eligible Items FSA Approved

Dynarex Bacitracin Ointment USP comes in single-use packets for ease of application and reduced chances of cross-contamination. It is another antibiotic cream for skin infection that you must have in your first aid kit to be prepared for emergencies.  

Active Ingredients 

  • Bacitracin (500 units)  

Features of Dynarex USP Ointment 

  • DEHP 
  • Latex-free 
  • Alcohol-free 
  • Helps reduce the risk of infection in burns and abrasions 
  • Inactive ingredients: hard paraffin, liquid paraffin, white soft paraffin 

Dynarex Bacitracin Ointment


Where can I buy the best antibiotic creams for skin infection online? 

HPFY has been online since 2002. We carry a range of wound and skin care products, including a selection of topical antibiotic creams for skin infections. Explore our catalog today to find the best pick for your needs.


Disclaimer: All content found on our website, including images, videos, infographics, and text were created solely for informational purposes. Our reviewed content should never be used for the purpose of diagnosis or treatment of any medical conditions. Content shared on our websites is not meant to be used as a substitute for advice from a certified medical professional. Reliance on the information provided on our website as a basis for patient treatment is solely at your own risk. We urge all our customers to always consult a physician or a certified medical professional before trying or using a new medical product.


HPFY Shweta Chaubey

Shweta Chaubey

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Shweta Chaubey, has been a Health Products For You contributor since 2021. An advocate-turned-writer, her desire to create meaningful and positive content has brought her to HPFY and what better than writing ...

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