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Ethicon Dermabond Advanced Topical Skin Adhesive

brand: ETHICON
Ethicon Dermabond Advanced Topical Skin Adhesive Dermabond Advanced Topical Skin Adhesive Ethicon Dermabond Advanced

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Item #: DNX12
Item #: DNX12
Item #: DNX6

Ethicon Dermabond Topical Skin Adhesive is a medical adhesive used for closing wounds, cuts, and incisions on the skin. It is a liquid adhesive that polymerizes quickly and forms a strong bond with the skin, creating a waterproof and protective seal that helps to reduce the risk of infection and scarring. Dermabond is made up of two components: 2-octyl cyanoacrylate and a stabilizer. When the two components are combined, they form a polymer that bonds to the skin and provides a secure closure. The adhesive is clear, so it does not obstruct the view of the wound, and it is flexible, which allows it to move with the skin as it heals.

Dermabond Glue Benefits

Demonstrated in vitro to kill 99.9% of bacteria (MRSA, MRSE, and E. coli) on direct contact
Provided strength to maintain barrier and wound closure integrity especially during critical wound healing period (48 hours)
Patient's Satisfaction
Patient Satisfaction
Offered comfort and convenience and led to excellent cosmesis
Economic Benefits
Economic Benefits
Reduced length of stay by more than 25% in CABG surgery, when used in addition to conventional sutures. Reduced hospitalization costs by $500 for C-sections when compared with staples or sutures alone

Dermabond Topical Skin Adhesive Features

  • Sterile, liquid topical skin adhesive containing a monomeric (2-octyl cyanoacrylate) formulation and the colorant D & C Violet No. 2
  • It is provided as a single use applicator in a blister package
  • The pen style applicator is composed of a crushable ampoule contained within a plastic applicator
  • As it is applied to the skin, the liquid is syrup-like in viscosity and polymerizes within minutes
  • Acts as a barrier to prevent microbial penetration as long as the adhesive remains
  • When used with sutures, Dermabond Advanced was shown ex vivo to add 75% more strength to the wound closure than sutures alone
  • Pen style applicator consists of a crushable ampoule contained within a plastic applicator
  • Adhesive will slough off usually within 5 to 10 days
  • Supplied in a blister package to maintain the sterility of the device until opened or damaged
  • Optimize surgeon experience
  • Embedded initiator technology to avoid clogging
  • Active Ingredient: 2-Octyl Cyanoacrylate
  • 0.7 mL formulation to close wounds up to 15 cm
  • Faster drying time in a single layer application
  • Cutting edge design for controlled fine and wide line application
  • Advanced silicone technology for easy activation and expression of adhesive
  • Provides a microbial barrier with 99% protection in vitro for at least 72 hours against organisms commonly responsible for surgical site infections 
Dermabond Features
Dermabond Advanced Topical Skin Adhesive Benefits

When to use Dermabond Surgical Glue?

  • Dermabond Advanced Adhesive is intended for topical application only to hold closed easily approximated skin edges of wounds from surgical incisions, including incisions from minimally invasive surgery and simple, thoroughly cleansed trauma-induced lacerations.
  • May be used in conjunction with, but not in place of deep dermal stitches.

How does Dermabond work?

  • Dermabond works by polymerizing quickly and forming a strong bond with the skin.
  • The adhesive is applied to the wound site, where it solidifies and creates a waterproof and protective seal.
  • This seal helps to reduce the risk of infection and scarring.

Frequently Bought Together

How to use Dermabond Skin Glue?

  1. The application of this adhesive requires thorough wound cleansing. Follow standard surgical practice for wound preparation before applying (i.e., anesthetize, irrigate, debride, ensure hemostasis, and close deep layers making sure that the wound edges can be easily approximated).
  2. Pat the wound dry with dry, sterile gauze to ensure direct contact of the topical skin adhesive to the skin. Moisture accelerates Dermabond Advanced Adhesive’s polymerization and may affect wound closure results.
  3. To prevent the inadvertent flow of skin glue to unintended areas of the body, the wound should be maintained in a horizontal position and the skin adhesive should be applied from above the wound.
  4. It should be used immediately after crushing the ampoule since the liquid will flow freely from the tip for only a few minutes.
  5. Refer to the instructions on the package for crushing the ampoule and expressing the liquid adhesive. Remove the applicator from the blister package. Hold the applicator with the thumb and a finger away from the patient to prevent any unintentional placement of the liquid into the wound or on the patient. With the applicator tip pointing downward, apply pressure at the midpoint of the bulb to crush the ampoule. Gently squeeze the applicator sufficiently to moisten the internal filter with the liquid adhesive. Stop squeezing and allow the liquid to draw back into the applicator.
  6. Approximate the wound edges with gloved fingers or sterile forceps. Slowly apply the liquid in one continuous layer to the surface of the approximated wound edges using a gentle brushing motion. Maintain manual approximation of the wound edges for approximately 60 seconds after the application. The width of the layer can be increased or decreased by adjusting the amount of pressure applied to the bulb during application.
    Note: Dermabond Advanced Adhesive polymerizes through an exothermic reaction in which a small amount of heat is released. Apply in one continuous layer. Apply in one continuous layer onto a dry wound will minimize the sensation of heat. Applying a second layer is not required or recommended. If the second layer is applied or if large droplets of liquid are not spread thinly, the patient may experience an increased sensation of heat or discomfort. Avoid excessive pressure of the applicator tip against the wound edges or surrounding skin to avoid forcing the wound edges apart and allowing it into the wound. Full apposition strength is expected to be achieved within minutes after the adhesive is applied. Full polymerization is expected when it is no longer sticky.
  7. Do not apply liquid or ointment medications onto closed wounds because these substances can weaken the polymerized film, leading to dehiscence (skin edge separation).
  8. Protective dry dressings such as gauze may be applied only after adhesive film is completely polymerized: not tacky to the touch after a few minutes. Allow the skin adhesive to fully polymerize before applying a bandage.
  9. Patients should be instructed not to pick at the polymerized film of skin adhesive. Picking at the film can disrupt its adhesion to the skin and cause dehiscence (skin edge separation).
  10. Patients should be instructed that until the polymerized film of adhesive has sloughed naturally (usually in 5–10 days), there should be only transient wetting of the treatment site. Patients may immediately shower or bathe the site gently as directed by their physician. The site should not be scrubbed, soaked, or exposed to prolonged wetness until after the film has sloughed naturally and the physician has determined that the wound is adequately healed. Patients should be instructed not to swim during this period.
  11. If removal of adhesive is necessary for any reason, carefully apply petroleum jelly or acetone to the dermabond skin glue to help loosen the bond. Peel off the film; do not pull the skin edges apart.

How to store?

  • Recommended storage conditions: below 30°C, 86°F, away from moisture, direct heat, and direct light. Do not use after the expiry date.


  • Do not use on any wound with evidence of active infection, gangrene, or wounds of decubitus etiology.
  • Do not use on mucosal surfaces or across mucocutaneous junctions (e.g., oral cavity, lips), or on the skin, which may be regularly exposed to body fluids or with dense natural hair (e.g., scalp).
  • Do not use on patients with a known hypersensitivity to cyanoacrylate, formaldehyde, or benzalkonium chloride.


  • Do not apply liquid or ointment medications or other substances to the wound after closure as these substances can weaken the polymerized film and allow for dehiscence (skin edge separation). Prior to application, cleanse the application site thoroughly to remove any remaining blood, fluids or topical medications/anesthetics.
  • It is syrup-like in viscosity. To prevent the inadvertent flow of liquid Dermabond Advanced Adhesive to unintended areas, the wound should be maintained in a horizontal position, applied from above.
  • Hold the applicator away from yourself and the patient with the tip pointing down and break the ampoule close to the center of the bulb one time only. Do not crush the contents of the applicator repeatedly as further manipulation of the applicator may cause glass shard penetration of the outer tube. Glass shard penetration can result in inadvertent skin punctures, which may result in the transmission of bloodborne pathogens.
  • Should be used immediately after crushing the ampoule because the adhesive will polymerize in the applicator, rendering the device unusable.
  • If unintended bonding of intact skin occurs, peel the adhesive from the skin, but do not pull the skin edges apart. Petroleum jelly or acetone may help loosen the bond. Other agents such as water, saline, or soap are not expected to immediately loosen the bond.

How to care for wounds after it is treated with this Skin Adhesive?

Dermabond Advanced Adhesive is a sterile, liquid skin adhesive that holds wound edges together. The film will usually remain in place for 5 to 10 days, then naturally fall off the skin. The following will answer some of your questions and provide instructions for proper care for your wound while it is healing.

Check Wound Appearance

  • Some swelling, redness, and pain are common with all wounds and normally will go away as the wound heals. If swelling, redness, or pain increases, or if the wound feels warm to the touch, contact a doctor. Also contact a doctor if the wound edges reopen or separate.

Caring for Bandages

  • If your wound is bandaged, keep the bandage dry
  • When changing the dressing, do not place tape directly over the adhesive because removing the tape later may also remove the film

Avoid Topical Medications

  • Do not apply liquid or ointment medications or any other product to your wound while the Dermabond Advanced Adhesive is in place. These may loosen the film before your wound is healed.

Keep Wound Dry and Protected

  • Apply a clean, dry bandage over the wound if necessary to protect it
  • You may occasionally and briefly wet your wound in the shower or bath. Do not soak or scrub your wound, do not swim, and avoid periods of heavy perspiration until the Dermabond Advanced Adhesive has naturally fallen off
  • After showering or bathing, gently blot your wound dry with a soft towel. If a protective dressing is being used, apply a fresh, dry bandage, keeping the tape on the adhesive
  • Protect your wound from injury until the skin has had sufficient time to heal
  • Do not scratch, rub, or pick. This may loosen the film before your wound is healed
  • Protect the wound from prolonged exposure to sunlight or tanning lamps while the film is in place

Dermabond Topical Skin Adhesive Guides

Frequently Asked Questions

What types of wounds is Dermabond suitable for?

It is suitable for certain types of wounds, such as clean, straight incisions, lacerations, and surgical incisions that are less than 5 cm long. It may not be appropriate for wounds that are contaminated, infected, or in areas that are difficult to close with an adhesive.

Is it painful to apply or remove Dermabond Glue?

It is generally painless. Some patients may feel a slight burning or stinging sensation when the adhesive is applied, but this usually subsides quickly. Removal is also generally painless, and the adhesive will eventually slough off on its own as the wound heals.

How long does Dermabond Glue stay on the skin?

It will typically stay on the skin for about 5-10 days, after which it will start to slough off on its own. In some cases, the adhesive may come off earlier if it is exposed to water or if it is rubbed or scratched.

Can Dermabond be used on children or pregnant women?

Can be used on children and pregnant women, but medical professionals will evaluate each case individually to determine if it is an appropriate treatment option.

Are there any risks or side effects?

Like any medical procedure, there are some risks and potential side effects associated with the use of Dermabond. These may include allergic reactions, wound dehiscence, and delayed healing. However, these risks are generally low, and medical professionals will carefully evaluate each case to minimize any potential complications.

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