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Benadryl Itch Relief Strength Cream

Brand: MCKESSON SKU: 501320101
Authorized Retailer
Product Option

1oz, Tube

SKU 501320101
$12.25 Each
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Benadryl Cream has an extra strength itch relief antihistamine cream that protects the skin. Dries the oozing & weeping of poison ivy, poison oak & poison sumac. Provides relief from minor pain and skin itching.

Benadryl Cream Benefits

  • Provides a cooling and soothing sensation
  • Easy to apply and absorbs quickly into the skin
  • Non-greasy and leaves no residue
  • Effective at relieving pain and itching
  • Helps to reduce swelling and redness


$9.80 $15.95

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One-time purchase

$12.25 $15.95

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Benadryl Anti Itch Cream Features

  • The topical gel provides fast cooling relief from skin pain & itching from most outdoor itches
  • Formula contains with 1% diphenhydramine hydrochloride topical analgesic and 0.1% zinc acetate skin protectant
  • The primary purpose of this cream is to provide relief from itching, burning, and discomfort caused by various skin irritations
  • Great to keep on hand for extra strength itch relief during outdoor activities such as camping, hiking, or taking a walk with the family
  • Designed to soothe itching and discomfort shortly after it's applied to the affected area
  • Gives cooling sensation when applied, which can help alleviate the sensation of itching and irritation
  • Made with 2% diphenhydramine hydrochloride, a topical analgesic pain reliever

When should you use this cream?

  • Insect bites
  • Rashes due to poison ivy, poison oak & poison sumac
  • Mosquito bites
  • Sunburn
  • Minor cut & scrapes

Ingredients of Benadryl Itch Stopping Cream

  • Active Ingredients:
    • Diphenhydramine HCI (2%) as a Topical Analgesic
    • Zinc Acetate (0.1%) as a Skin Protectant
  • Inactive Ingredients:
    • Cetyl alcohol
    • Diazolidinyl urea
    • Methylparaben
    • Polyethylene glycol monostearate 1000
    • Propylene glycol
    • Propylparaben
    • Purified water

Frequently Bought Together

How to Use Benadryl Itch Stopping Cream?

  • Gently clean the affected area with mild soap and water before applying the cream.
  • Squeeze a small amount of Benedryl itch-stopping cream on your finger or a cotton swab.,/li>
  • Apply a thin layer on the itchy area directly on the skin and massage it until it is completely absorbed.
  • Reapply the cream every 5 to 8 hours depending on the severity of the itch and the irritated area.,/li>
  • After applying, thoroughly wash your hands to remove any residue from your fingers.
    • Note: Avoid rubbing the cream aggressively on the area that is already irritated.
    • Avoid contact with your eyes and irritated skin.

Side Effect of Benadryl Ointment

Stop using this product and tell your doctor right away if any of the following serious side effects occur:

  • Enlarged pupils in the eyes
  • Face flushing
  • Mental/mood changes such as hallucinations, unusual excitement, confusion
  • difficulty walking
  • Severe dizziness
  • Trouble breathing


  • For external use only
  • Do not use
    • On large areas of the body
    • With any other product containing diphenhydramine, even one taken by mouth
  • Ask a doctor before use
    • On chicken pox
    • On measles
  • When using this product
    • Avoid contact with eyes
  • Stop using and ask a doctor if
    • The condition worsens or does not improve within 7 days
    • Symptoms persist for more than 7 days or clear up and occur again within a few days
  • Keep out of reach of children
  • If swallowed, get medical help

Frequently Asked Questions

How long does Benadryl Cream take to work?

Benadryl Anti Itch Cream typically starts to work within minutes of application. However, the full effects of the cream may not be felt for up to 30 minutes.

How often can I use Benadryl Anti Itch Cream?

You can use this cream as often as needed, up to 3 times a day. However, it is important to avoid using the cream too often, as this could lead to side effects such as drowsiness and dry skin.

Is Benadryl for Itchy Skin safe for children?

Benadryl Cream is generally safe for children to use. However, it is important to talk to your doctor before using the cream on children under the age of 2.

Can I use Benadryl Cream on my face?

It is not recommended to use this cream on your face. The cream can be irritating to the delicate skin of the face. If you need to use the cream on your face, be sure to apply it sparingly and rinse it off thoroughly after 30 minutes.

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