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How Does Biofreeze Work?

How Does Biofreeze Work?
Sailaxmi Chennuru

We all experience aches and pains at some point in our lives. When it comes to pain management, topical pain relief creams may ease discomfort with fewer side effects than oral pain relievers. One such topical pain reliever that gets consistently high marks is Biofreeze.

What is Biofreeze?

It is a known fact that ice helps relieve pain and speeds up recovery when applied to the affected area. Biofreeze is a topical analgesic that works similarly to cold therapy, reducing inflammation and improving circulation, but offers more powerful, comfortable, and long-lasting pain relief. 

The Biofreeze pain reliever is formulated with menthol to provide temporary cooling relief for muscle and joint pain. It is available in gel, spray, or roll-on, penetrates the skin quickly, and relieves pain naturally. Biofreeze delivers relief from-

How Does Biofreeze Work?

We feel pain because nerve receptors send signals from the point of pain to the spinal cord and then to the brain. Like any other topical pain reliever, Biofreeze pain relief products work by the "pain gate” or “gate control” theory. The "gate" is part of the spinal cord where pain signals travel through or are restricted. If the gate is open, pain signals are transmitted to the brain, and we perceive pain. If the gate is closed, the sensation of pain won't be recognized.

what does bio freeze do

When Biofreeze gel or cream is applied to a painful area, a cold sensation is created, which overrides signals to the brain and reduces pain. In addition, Biofreeze increases blood flow to the infected area eliminates toxins more efficiently, and delivers oxygen and nutrients to the cells. This is how Biofreeze works for pain relief.

Biofreeze Ingredients

The active ingredients in Biofreeze include - 

  • Menthol
  • Isopropyl Alcohol
  • Triethanolamine 
  • Ethyl Alcohol

How to use Biofreeze?

Biofreeze is for use on the skin only. Read the package insert for more specific directions.

  • Apply cream, gel, or liquid to the affected area and rub gently.
  • Do not use Biofreeze pain relieving gel more than 3 to 4 times daily.
  • Wash your hands well after applying. 

Some things to avoid when using Biofreeze - 

  • Do not apply on cuts, wounds, burns, rashes, or irritated skin.
  • Do not tightly wrap or bandage the area where Biofreeze is applied.
  • Biofreeze works by creating a cooling sensation. Do not use a tanning bed, sun lamp, hot water bottle, or heating pad on the treated area. Using it with heat could cause serious injuries.
  • Avoid getting Biofreeze in your eyes, nose, or mouth. If that happens, flush with plenty of water.

Biofreeze Side Effects

Following may be some common side effects of Biofreeze.

  • Skin irritation
  • Itchiness or burning sensation
  • Blisters or peeling off of the skin
  • People prone to allergies may experience difficulty breathing, swelling, or severe dizziness. 

Consult your doctor immediately if any of these symptoms surface. 

Top 5 Biofreeze Products at HPFY

1. Biofreeze Professional Pain Relieving Gel

FSA Eligible Items FSA Approved Made in USA Made In USA

Designed to relieve pain, reduce joint stiffness, and increase range of motion. Biofreeze gel effectively alleviates back aches, arthritic pain, sore muscles and joints, sprains, strains, and bruises. The fast-acting proprietary formula is made with U.S. Pharmacopeia-grade ingredients and is free of parabens and propylene glycol. 

This sought-after pain relief gel is trusted and recommended by physical therapists, chiropractors, massage therapists, podiatrists, athletic trainers, and other medical professionals. It is available in a small 4 oz tube that is easy to carry while on the go.

Why choose Biofreeze Gel?

  • Clinically proven pain-relieving gel.
  • Fast-acting and long-lasting.
  • Contains menthol, a natural pain reliever.
  • Smooth consistency for easy application
  • Does not contain NSAIDs, salicylates, or addictive substances.
  • Also available in a dye-free formula.

Biofreeze Professional Customer Reviews

5 Star Reviews on Biofreeze Professional Gel


12/15/22 by Paula L.  "Very easy to use and works great. I just got a sample but I'm going to order a larger tube now. "

Biofreeze Professional Pain Relieving Gel



2. Biofreeze Professional Pain Relieving Roll-On

FSA Eligible Items FSA Approved Made in USA Made In USA

Designed with a roll-on applicator for easy application and offers all the sought-after pain-relieving qualities of  Biofreeze. The fast-acting, cooling menthol formula penetrates quickly and delivers pain relief for arthritis, sore muscles and joints, and injuries such as sprains, strains, and bruises. Biofreeze roll-on is perfect for applying an even amount to the desired area.

Why choose Biofreeze Roll On?

  • Formulated with pain-relieving menthol
  • Clinically recommended brand.
  • Hands-free application without mess.
  • Made with USP-grade ingredients
  • Free of parabens and propylene glycol.
  • FSA/HSA eligible

Biofreeze Professional Pain Relieving Roll-On Customer Reviews

5 Star Reviews on Biofreeze Professional Pain Relieving Roll-On


12/13/22 by Lorraine M. "I'm always with Bio Freeze whenever I have a problem with any of my joints or muscles, it relieves the area and my pain subsides."

Biofreeze Professional Pain Relieving Roll-On



3. Biofreeze Professional Pain Relieving Gel Pump

FSA Eligible Items FSA Approved Made in USA Made In USA

The convenient pump bottle applies quickly and easily, making it ideal for training rooms, gyms, or clinics. Biofreeze Gel allows you to stay active by treating aches, pains, sprains, and strains. It is suitable for use on most areas of the body, including the back, neck, shoulders, hands, hips, legs, and feet. The soothing menthol formula is cooling and absorbs quickly into the skin without a strong, lingering scent. 

5 Benefits of Biofreeze Professional Gel

  • Relieves aches and pains
  • Fast absorbing
  • Long-lasting results
  • Prevents dry skin
  • Safe pain management

Biofreeze Professional Pain Relieving Gel Pump Customer Reviews

5 Star Reviews on Biofreeze Professional Pain Relieving Gel Pump


11/13/21 by Babu N. "Good "

Biofreeze Professional Pain Relieving Gel Pump



4. Biofreeze Professional Spray

FSA Eligible Items FSA Approved Made in USA Made In USA

The convenient spray bottle makes application easy, especially for those with arthritis and dexterity issues. Made of 100% natural ingredients,  Biofreeze spray offers quick pain relief to let you get on with your daily activities. A great alternative to other pain relievers because it is non-systemic, non-narcotic, and contains no NSAIDs (non-steroidal anti-inflammatory drugs), salicylates, or addictive substances.

Benefits of Biofreeze Spray

  • Clinically recommended topical pain reliever.
  • Helps relax muscles and soothe aches and pains. 
  • The cooling effect increases circulation
  • Long-lasting pain relief.
  • Leaves no greasy residue and won’t stain clothes.
  • Hands-free application- perfect for smaller areas.
  • Dye-free.

Biofreeze Professional Pain Relieving Spray Customer Reviews

5 Star Reviews on Biofreeze Professional Pain Relieving Spray


11/12/22 by Henry C. "I went to a chiroprator for years until I discovered Biofreeze. Now I use Biofreeze and some time Ibuprofen and reliev is instant. Until I contacted Parkinsons, I used to spend hours in my yard and neighbors were amazed. I have told many people about Biofreeze and was pleased to hear of their experiences. All good :) "

Biofreeze Professional Pain Relieving Spray



5. Biofreeze Classic Pain Relief

FSA Eligible Items FSA Approved

A topical pain reliever offering a safer alternative to oral painkillers like ibuprofen and aspirin. Biofreeze Classic’s clinically proven formula has been providing pain relief to sore muscles and joints for over 25 years. Trusted by chiropractors, physical therapists, trainers, and healthcare professionals, this pain-relieving gel is effective for almost all types of pain. Made with USP-grade ingredients, it is free of propylene glycol and parabens.

Application of Biofreeze Classic Pain Reliever

Biofreeze is available in different application styles to provide convenient relief for almost any type of pain.

  • Biofreeze Spray: Mess-free application for hard-to-reach places.
  • Biofreeze Gel tube/pump: Effective for larger muscle areas needing more coverage, like the hip, leg, or back.
  • Biofreeze Roll On: Delivers an even coat of ointment and helps massage muscles. 
Biofreeze Classic Pain Relief



Before using Biofreeze, read all directions on the product package or follow your doctor’s advice. If your condition does not improve or worsens, seek immediate medical care.

At HPFY, you will find our complete line of Biofreeze and other pain relief products. Shop now and live pain-free!


Disclaimer: All content found on our website, including images, videos, infographics, and text were created solely for informational purposes. Our reviewed content should never be used for the purpose of diagnosis or treatment of any medical conditions. Content shared on our websites is not meant to be used as a substitute for advice from a certified medical professional. Reliance on the information provided on our website as a basis for patient treatment is solely at your own risk. We urge all our customers to always consult a physician or a certified medical professional before trying or using a new medical product.


HPFY Sailaxmi Chennuru

Sailaxmi Chennuru

Sailaxmi Chennuru, has been a Health Products For You contributor since 2017. A business management graduate, the study of anatomy has always been of interest to her.

After working as a medical transcriptionist for several years, she developed a keen interest ...

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