Silvadene - Silver Sulfadiazine Cream For Burns

Brand/Manufacturer: PFIZER INC

Silvadene Topical Burn Cream (silver sulfadiazine) is a topical antimicrobial agent that’s applied directly to the wound site, most commonly, second-degree and third-degree burns. The burns should remain covered with the cream at all times to eliminate and reduce infection risks. Patients are advised to continue using the cream until the area has healed to an adequate level or until the wound is ready for skin grafting.

SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula:

Chemical formula of Silvadene

Ingredients of Silvadene Burn Cream

Each gram of Silvadene 1% Cream contains -
  • 10 mg of micronized silver sulfadiazine
  • White petrolatum
  • Stearyl alcohol
  • Isopropyl myristate
  • Sorbitan monooleate
  • Polyoxyl 40 stearate
  • Propylene glycol
  • Water
  • Methylparaben 0.3% as a preservative

Why Choose Silvadene?

  • Silvadene contains antimicrobial properties of sulfa drugs
  • It kills harmful microorganisms by attacking their cell membrane and their cell walls
  • This Burn care cream also suppresses the growth of bacteria and yeast-like Candida Albicans
  • Studies find Silvadene Cream to be better than Ag- PHEMA, Sulfamylon or cerium-Silvadene.
  • Silvadene Ointment can be applied and left open or covered by dressing, as per requirements.

What is Silver Sulfadiazine Cream used for?

Indications of Silvadene Topical Ointment

  • Second Degree Burns
  • Third Degree Burns
  • Severe Sunburns

Contraindications of Micronized Silver Sulfadiazine

  • Allergies and sensitivity to silver or any ingredients
  • Pregnancy
  • Premature infants
  • Infants below 2 months of age

Side Effects of Silvadene Burn Cream

  • Fatigue or weakness
  • Sore throat
  • Pain in joints
  • Yellowing of the eyes or skin
  • Transient leukopenia (decreased neutrophil count)
  • Skin necrosis
  • Erythema multiforme
  • Skin discoloration
  • Burning sensation
  • Rashes,
  • Interstitial nephritis
  • Unexplained bruising or bleeding
  • Blood in urine

If any of the above symptoms are visible in the patient, immediately contact the family doctor and stop using the cream until further clearance.


How to Apply Silvadene Topical Ointment?

Cleaning the wound
1. Clean the wound site, remove any debris or dead and burnt skin

Wear Medical Gloves
2. Wear gloves if applying by hand

Apply Silvadene Silver Sulfadiazine Cream
3. Apply a thin layer of cream covering the wound and perineal area

Apply Bandage
4. Cover the wound or keep it open as per advised

Reapply when cream wears off
5. Reapply the ointment once it wears off every few hours

Administered Dosage of Silvadene for Burns

  • Grown ups are required to apply Silvadene twice a day and reapply when it wears off from daily tasks
  • It is advised to consult a physician for dosage requirements of a child
  • Users are recommended to continue use of Silvadene until the wound has healed or the site is ready for skin grafting.

Silvadene Silver Sulfadiazine Cream - FAQs

  • How long should you use Silvadene on a burn?

    Silver Sulfadiazine Cream should be used throughout the day, every day, till the wound heals or the skin is ready for grafting.

  • How many times a day should you use Silvadene?

    Silvadene Cream should be applied twice-a-day in 10-12 hr. cycles and reapplied if it wears off in day-to-day tasks.

  • How long does it take for silver sulfadiazine to work?

    A study reveals that wound healing among users of SSD (Silver Sulfadiazine) was evident in 72% of patients by day 7, and 84% were completely healed by day 21.

  • Can you put Silvadene on an open wound?

    Yes, for most surface wounds applying Silvadene on an open wound after debriding will prevent infection and keep bacteria at bay.

  • What does Silvadene do for a burn?

    The Silver Sulfadiazine present in Silvadene Cream helps kill bacteria and prevent infection from spreading in the bloodstream that may cause severe issues like Sepsis.

  • Does Silvadene cream help with pain?

    Application of Silvadene on severe sunburns reported decreased pain and faster healing.

  • Does Silvadene turn skin black?

    No. The cream does turn black as the silver ion oxidizes, but the black pigments are not incorporated into the skin. The permanent discoloration that occurs is due to the burn and may eventually fade away.


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What is HPFY’s return policy?

Customer satisfaction is our top priority. We stand behind our products. If the merchandise you received is defective or not what you expected it to be, and you wish to return the item, please submit a return request in the My Account section of our website, contact our Customer Service department at (866) 316-0162 / (203) 616-2850 or email us.

  1. Merchandise must be returned within 30 days of the receipt of your order. Returns are not accepted after 30 days.
  2. Items (including parts and accessories) must be returned in new, unused, and resalable condition in its original packaging.
  3. Before returning any product, the buyer must obtain a Return Authorization Number (RA#) from a customer service representative. With your RA# you will receive a prepaid return shipping label.
  4. Orders returned without obtaining an RA# will be entitled to receive only "In-Store Credit" that can be used towards future purchases.
  5. Return orders are subject to a 20% restocking fees.
  6. All custom orders and hygienic items are non-returnable. Refer to the “Non-Returnable Items” section for further details.
  7. Returns will be reviewed and inspected before issuing credit. Please allow 3 to 4 weeks for processing. The credit will be applied to your original method of payment.
  8. If the return is the result of a defective product or shipping error, we will refund the entire purchase amount and return shipping costs.

Which products are Non-Returnable?

Due to the hygienic nature of some items, they are non-returnable. The items listed below are non-returnable:

  1. All hygienic items.
  2. Opened personal care items.
  3. Anything opened, used, or tried on.
  4. All customized items.
  5. Besides these, items that have the “non-returnable” phrase on the website.

We reserve the right to make adjustments due to errors, changing market conditions, product discontinuation or typographical errors in advertisements. Images on the site may not always reflect the actual product. Footrests or leg-rests are not included with wheelchairs unless specified.

How do I receive a return authorization number?

You can submit a return request by logging into your account. You will receive the Return Authorization Number (RA#) details in the email within 2-3 business days.

  • Login to your account
  • Go to “order history”
  • Click on “return order”
  • Fill out the return form and Submit it

If you do not have an email address, we will make other accommodations for RA# Details. Write the RA# on your label affixed to your package prior to shipment.

How long does it take to receive a refund?

Please allow 3 to 4 weeks to process the returns. Once the item is received, and inspected, your refund will be processed and automatically applied to your credit card or original method of payment.

Is there any Restocking Fees?

  1. 20% restocking fees will be applied.
  2. Outbound shipping cost is non-refundable.
  3. For orders that qualified for free shipping, $8.99 will be deducted from the refund if the product is returned.

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